Paraceta, also known as acetaminophen, is a medication used to treat pain and fever.[᱑᱒][᱑᱓] It is typically used for mild to moderate pain relief.[᱑᱒] Evidence is mixed for its use to relieve fever in children.[᱑᱔][᱑᱕] It is often sold in combination with other medications, such as in many cold medications.[᱑᱒] Paracetamol is also used for severe pain, such as cancer pain and pain after surgery, in combination with opioid pain medication.[᱑᱖] It is typically used either by mouth or rectally, but is also available by injection into a vein.[᱑᱒][᱑᱗] Effects last between two and four hours.[᱑᱗]

Clinical data
Pronunciation ᱯᱟᱨᱟᱥᱤᱴᱟᱢᱳᱞ: /ˌpærəˈstəmɒl/
ᱮᱥᱤᱴᱟᱢᱤᱱᱳᱯᱷᱮᱱ: /əˌstəˈmɪnəfn/
Trade names ᱴᱟᱭᱞᱤᱱᱳᱞ, ᱯᱟᱱᱟᱰᱳᱞ, ᱮᱴᱟᱜᱟᱜ ᱠᱚ[᱒]
Synonyms ᱪᱷᱟᱸᱪ:Infobox drug/localINNvariants
AHFS/ Monograph
MedlinePlus a681004
Routes of
By mouth, through the cheek, rectal, intravenous (IV)
Drug class Analgesics and antipyretics
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 63–89%[᱔]:73
Protein binding 10–25%[᱕]
Metabolism Predominantly in the liver[᱓]
Metabolites APAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI[᱖]
Onset of action Pain relief onset by route:
By mouth – 37 minutes[᱗]
Buccal – 15 minutes[᱗]
Intravenous – 8 minutes[᱗]
Elimination half-life 2–2.5 hours[᱘]
Excretion Urine (85–90%)[᱓]
CAS Number
PubChem CID
PubChem SID
PDB ligand
ECHA InfoCard 100.002.870 Edit this at Wikidata
Chemical and physical data
Formula C8H9NO2
Molar mass Error in {{val}}: parameter 1 is not a valid number. g·mol−1
3D model (JSmol)
Density 1.263 g/cm3
Melting point 169 °C (336 °F) [᱑᱐][᱑᱑]
Boiling point 420 °C (788 °F)
Solubility in water
  • 7.21 g/kg (0 °C)[᱙]
  • 8.21 g/kg (5 °C)[᱙]
  • 9.44 g/kg (10 °C)[᱙]
  • 10.97 g/kg (15 °C)[᱙]
  • 12.78 g/kg (20 °C)[᱙]
  • ~14 mg/ml (20 °C)

Paracetamol is generally safe at recommended doses.[᱑᱘][᱑᱙] The recommended maximum daily dose for an adult is three to four grams.[᱒᱐][᱒᱑][᱑᱙] Higher doses may lead to toxicity, including liver failure.[᱑᱒] Serious skin rashes may rarely occur.[᱑᱒] It appears to be safe during pregnancy and when breastfeeding.[᱑᱒] In those with liver disease, it may still be used, but in lower doses.[᱒᱒] It is classified as a mild analgesic.[᱑᱗] It does not have significant anti-inflammatory activity.[᱒᱓] How it works is not entirely clear.[᱒᱓][᱒᱔][᱒᱕]

Paracetamol was first made in 1877.[᱒᱖] It is the most commonly used medication for pain and fever in both the United States and Europe.[᱒᱗] It is on the World Health Organization's List of Essential Medicines.[᱒᱘] Paracetamol is available as a generic medication, with brand names including Tylenol and Panadol among others.[᱒᱙] In 2017, it was the 25th-most commonly prescribed medication in the United States, with more than 24 million prescriptions.[᱓᱐][᱓᱑]ᱪᱷᱟᱸᱪ:TOC limit

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