Paraceta, also known as acetaminophen, is a medication used to treat pain and fever.[᱑᱒][᱑᱓] It is typically used for mild to moderate pain relief.[᱑᱒] Evidence is mixed for its use to relieve fever in children.[᱑᱔][᱑᱕] It is often sold in combination with other medications, such as in many cold medications.[᱑᱒] Paracetamol is also used for severe pain, such as cancer pain and pain after surgery, in combination with opioid pain medication.[᱑᱖] It is typically used either by mouth or rectally, but is also available by injection into a vein.[᱑᱒][᱑᱗] Effects last between two and four hours.[᱑᱗]

ᱯᱟᱨᱟᱥᱤᱴᱟᱢᱳᱞ
Paracetamol-skeletal.svg
Paracetamol-from-xtal-3D-balls.png
Clinical data
Pronunciation ᱯᱟᱨᱟᱥᱤᱴᱟᱢᱳᱞ: /ˌpærəˈstəmɒl/
ᱮᱥᱤᱴᱟᱢᱤᱱᱳᱯᱷᱮᱱ: /əˌstəˈmɪnəfn/
Trade names ᱴᱟᱭᱞᱤᱱᱳᱞ, ᱯᱟᱱᱟᱰᱳᱞ, ᱮᱴᱟᱜᱟᱜ ᱠᱚ[᱒]
Synonyms ᱪᱷᱟᱸᱪ:Infobox drug/localINNvariants
AHFS/Drugs.com Monograph
MedlinePlus a681004
data
Pregnancy
category
Routes of
administration
By mouth, through the cheek, rectal, intravenous (IV)
Drug class Analgesics and antipyretics
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 63–89%[᱔]:73
Protein binding 10–25%[᱕]
Metabolism Predominantly in the liver[᱓]
Metabolites APAP gluc, APAP sulfate, APAP GSH, APAP cys, NAPQI[᱖]
Onset of action Pain relief onset by route:
By mouth – 37 minutes[᱗]
Buccal – 15 minutes[᱗]
Intravenous – 8 minutes[᱗]
Elimination half-life 2–2.5 hours[᱘]
Excretion Urine (85–90%)[᱓]
Identifiers
CAS Number
PubChem CID
PubChem SID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
ECHA InfoCard 100.002.870 Edit this at Wikidata
Chemical and physical data
Formula C8H9NO2
Molar mass Error in {{val}}: parameter 1 is not a valid number. g·mol−1
3D model (JSmol)
Density 1.263 g/cm3
Melting point 169 °C (336 °F) [᱑᱐][᱑᱑]
Boiling point 420 °C (788 °F)
Solubility in water
  • 7.21 g/kg (0 °C)[᱙]
  • 8.21 g/kg (5 °C)[᱙]
  • 9.44 g/kg (10 °C)[᱙]
  • 10.97 g/kg (15 °C)[᱙]
  • 12.78 g/kg (20 °C)[᱙]
  • ~14 mg/ml (20 °C)
  (verify)

Paracetamol is generally safe at recommended doses.[᱑᱘][᱑᱙] The recommended maximum daily dose for an adult is three to four grams.[᱒᱐][᱒᱑][᱑᱙] Higher doses may lead to toxicity, including liver failure.[᱑᱒] Serious skin rashes may rarely occur.[᱑᱒] It appears to be safe during pregnancy and when breastfeeding.[᱑᱒] In those with liver disease, it may still be used, but in lower doses.[᱒᱒] It is classified as a mild analgesic.[᱑᱗] It does not have significant anti-inflammatory activity.[᱒᱓] How it works is not entirely clear.[᱒᱓][᱒᱔][᱒᱕]

Paracetamol was first made in 1877.[᱒᱖] It is the most commonly used medication for pain and fever in both the United States and Europe.[᱒᱗] It is on the World Health Organization's List of Essential Medicines.[᱒᱘] Paracetamol is available as a generic medication, with brand names including Tylenol and Panadol among others.[᱒᱙] In 2017, it was the 25th-most commonly prescribed medication in the United States, with more than 24 million prescriptions.[᱓᱐][᱓᱑]ᱪᱷᱟᱸᱪ:TOC limit

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