ᱨᱮᱫ:Serpin mechanism.png
ᱧᱮᱞᱡᱚᱝ ᱨᱮᱱᱟᱜ ᱟᱠᱟᱨ:᱗᱒᱕ × ᱕᱙᱙ ᱯᱤᱠᱥᱮᱞ ᱮᱴᱟᱜ ᱨᱤᱡᱚᱞᱩᱥᱚᱱᱥ: ᱒᱙᱐ × ᱒᱔᱐ ᱯᱤᱠᱥᱮᱞ | ᱕᱘᱑ × ᱔᱘᱐ ᱯᱤᱠᱥᱮᱞ | ᱙᱒᱙ × ᱗᱖᱘ ᱯᱤᱠᱥᱮᱞ | ᱑,᱒᱓᱙ × ᱑,᱐᱒᱔ ᱯᱤᱠᱥᱮᱞ | ᱑,᱘᱐᱐ × ᱑,᱔᱘᱘ ᱯᱤᱠᱥᱮᱞ
ᱟᱥᱚᱞ ᱨᱮᱫ (᱑,᱘᱐᱐ x ᱑,᱔᱘᱘ pixels, file size: ᱕᱑᱓ KB, MIME type: image/png)
ᱢᱩᱬᱩᱛ ᱠᱟᱛᱷᱟ
| ᱵᱤᱵᱚᱨᱚᱱᱤ |
English: Serine proteases operate by a two-step catalytic mechanism. First, the substrate (blue) is attacked by the catalytic triad (red) to form an acyl-enzyme intermediate. The intermediate is typically resolved by hydrolysis by water. However, when the reactive centre loop (RCL) of a serpin is attacked, the conformational change (blue arrow) pulls the catalytic triad out of position, preventing it from completing catalysis. (Based on PDB: 1K9O, 1EZX) |
| ᱢᱟᱹᱦᱤᱛ | |
| ᱯᱷᱮᱰᱟᱛ | ᱤᱧᱟᱜ ᱠᱟᱹᱢᱤ |
| ᱚᱱᱚᱞᱤᱭᱟᱹ | Thomas Shafee |
ᱞᱟᱭᱥᱮᱱᱥ ᱛᱮᱭᱟᱨ
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution 4.0 International license.
- ᱟᱲᱟᱜ ᱜᱮᱭᱟᱢ:
- ᱦᱟᱹᱴᱤᱧᱢᱮ – ᱱᱚᱠᱚᱞ ᱞᱟᱹᱜᱤᱫ, ᱦᱟᱹᱴᱤᱧ ᱟᱨ ᱵᱷᱮᱡᱟᱭᱢᱮ ᱠᱟᱹᱢᱤ
- ᱢᱮᱥᱟᱣᱠᱟᱛᱢᱮ – ᱠᱟᱹᱢᱤ ᱟᱞᱜᱟᱭ ᱞᱟᱹᱜᱤᱫ
- ᱞᱟᱛᱟᱨ ᱨᱮᱭᱟᱜ ᱨᱤᱛ ᱞᱮᱠᱟᱛᱮ:
- ᱟᱴᱨᱤᱵᱩᱥᱚᱱ – ᱟᱢ ᱠᱟᱹᱢᱤ ᱥᱚᱫᱚᱨ ᱦᱩᱭᱟᱢᱟ ᱡᱚᱠᱷᱚᱱ ᱚᱱᱚᱞᱤᱭᱟᱹ ᱟᱨᱵᱟᱝ ᱞᱟᱭᱥᱮᱸᱥᱩᱭᱟᱹ ᱫᱟᱨᱟᱭᱛᱮ ᱠᱟᱛᱷᱟ ᱨᱟᱠᱟᱵ ᱠᱷᱟᱱ (ᱢᱮᱱᱠᱷᱟᱱ ᱟᱠᱚ ᱩᱫᱩᱜᱟᱜ ᱦᱚᱨ ᱛᱮᱫᱚ ᱵᱟᱝ ᱡᱟᱦᱟᱸ ᱟᱠᱚᱠᱚ ᱜᱚᱲᱚᱣᱟᱢ ᱟᱨᱵᱟᱝ ᱟᱢᱟᱜ ᱠᱟᱹᱢᱤ ᱨᱮᱱᱟᱜ ᱵᱮᱵᱷᱟᱨ)
ᱨᱮᱫ ᱨᱮᱭᱟᱜ ᱱᱟᱜᱟᱢ
ᱚᱠᱛᱚ ᱨᱮ ᱞᱤᱱ ᱢᱮ/ᱚᱠᱛᱚ ᱨᱮ ᱨᱮᱫ ᱧᱮᱞ ᱞᱟᱹᱜᱤᱛ ᱞᱤᱱ ᱢᱮ
| ᱢᱟᱹᱦᱤᱛ/ᱚᱠᱛᱚ | ᱴᱤᱯ | ᱡᱚᱠᱷᱟ | ᱵᱮᱵᱷᱟᱨᱤᱭᱟᱹ | ᱠᱟᱛᱷᱟ | |
|---|---|---|---|---|---|
| ᱱᱤᱛᱚᱜ | ᱐᱙:᱕᱖, ᱒᱒ ᱰᱤᱥᱮᱢᱵᱚᱨ ᱒᱐᱑᱕ | | ᱑,᱘᱐᱐ × ᱑,᱔᱘᱘ (᱕᱑᱓ KB) | Evolution and evolvability | Higher resolution |
| ᱐᱕:᱑᱙, ᱑᱙ ᱰᱤᱥᱮᱢᱵᱚᱨ ᱒᱐᱑᱕ |  | ᱑,᱓᱖᱒ × ᱑,᱑᱒᱖ (᱓᱐᱐ KB) | Evolution and evolvability | Minor arrow correction | |
| ᱐᱕:᱐᱘, ᱑᱙ ᱰᱤᱥᱮᱢᱵᱚᱨ ᱒᱐᱑᱕ |  | ᱑,᱓᱖᱒ × ᱑,᱑᱒᱖ (᱓᱐᱐ KB) | Evolution and evolvability | added arrow and removed transparency | |
| ᱐᱕:᱐᱔, ᱑᱙ ᱰᱤᱥᱮᱢᱵᱚᱨ ᱒᱐᱑᱕ |  | ᱑,᱓᱖᱒ × ᱑,᱑᱑᱔ (᱓᱖᱐ KB) | Evolution and evolvability | Cross-wiki upload from en.wikipedia.org |
ᱯᱷᱟᱭᱤᱞ ᱵᱮᱣᱦᱟᱨ
ᱱᱚᱸᱰᱮ ᱫᱚ ᱟᱨ ᱮᱴᱟᱜ ᱥᱟᱦᱴᱟᱠᱚ ᱵᱟᱱᱩᱜ-ᱟ ᱡᱟᱸᱦᱟᱸ ᱥᱟᱶᱛᱮ ᱱᱤᱭᱟᱹ ᱨᱮᱫ ᱨᱮᱱᱟᱜ ᱡᱚᱱᱚᱲ ᱢᱮᱱᱟᱜ-ᱟ
ᱡᱮᱜᱮᱛ ᱡᱟᱠᱟᱛ ᱨᱮᱫ ᱵᱮᱵᱷᱟᱨᱟᱜ
ᱱᱚᱶᱟ ᱨᱮᱫᱠᱚ ᱵᱮᱵᱷᱟᱨᱟᱠᱟᱫ ᱣᱤᱠᱤᱠᱚ :
